Wnt signaling in development and tissue homeostasis

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper...

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Published in	Development (Cambridge) Vol. 145; no. 11; p. dev146589
Main Authors	Steinhart, Zachary, Angers, Stephane
Format	Journal Article
Language	English
Published	England The Company of Biologists Ltd 01.06.2018
Subjects	Cancer Cell interactions Cell proliferation Cell signaling Embryogenesis Homeostasis Regenerative medicine Signal transduction Stem cells Wnt protein β-Catenin Wnt protein Epigenetics Wnt signaling
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Abstract	The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.
AbstractList	The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis. The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.Summary: An overview of Wnt-β-catenin signaling highlighting its key functions during development and adult tissue homeostasis. The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.
Author	Angers, Stephane Steinhart, Zachary
Author_xml	– sequence: 1 givenname: Zachary surname: Steinhart fullname: Steinhart, Zachary organization: University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada – sequence: 2 givenname: Stephane orcidid: 0000-0001-7241-9044 surname: Angers fullname: Angers, Stephane organization: University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29884654$$D View this record in MEDLINE/PubMed
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Snippet	The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation...
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SubjectTerms	Cancer Cell interactions Cell proliferation Cell signaling Embryogenesis Homeostasis Regenerative medicine Signal transduction Stem cells Wnt protein β-Catenin
Title	Wnt signaling in development and tissue homeostasis
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