Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators

Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantage...

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Bibliographic Details
Published inMolbank Vol. 5; no. 12; pp. 1439 - 1460
Main Authors Luu, Bang, Aguilar, Jose-Luis Gonzalez De, Girlanda-Junges, Celine
Format Journal Article Book Review
LanguageEnglish
Published Basel MDPI AG 01.12.2000
Subjects
cyclohexenonic long-chain fatty alcohol
neurite outgrowth
neuronal survival
neurotrophic compound
neurotrophic factor
NGF
synthesis
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Summary:Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
ISSN:1420-3049
1420-3049
1422-8599
DOI:10.3390/51201439