Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aq...

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Published inChinese journal of polymer science Vol. 32; no. 12; pp. 1590 - 1601
Main Authors Zhang, Yan-bo, Ding, Jian-xun, Xu, Wei-guo, Wu, Jie, Chang, Fei, Zhuang, Xiu-li, Chen, Xue-si, Wang, Jin-cheng
Format Journal Article
LanguageEnglish
Published Heidelberg Chinese Chemical Society and Institute of Chemistry, CAS 01.12.2014
Subjects
Bone marrow
Cartilage
Cellular
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Degradation
Hydrogels
Industrial Chemistry/Chemical Engineering
Polymer Sciences
Polymerization
Stem cells
Tissue engineering
三嵌段共聚物
两亲共聚物
可生物降解
培养基质
大分子引发剂
热凝胶
软骨组织工程
骨髓间充质干细胞
Scaffold
Thermogel
Bone marrow mesenchymal stem cell
Cartilage defect repair
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Summary:Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations（〉 15 wt%）. The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEGPLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.
Bibliography:Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations（〉 15 wt%）. The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEGPLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.
Bone marrow mesenchymal stem cell Cartilage defect repair Scaffold Thermogel.
11-2015/O6
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ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-014-1551-5