Antioxidant, Acetylcholinesterase, Butyrylcholinesterase, and α-glucosidase Inhibitory Activities of Corchorus depressus
( ) commonly known as Boa-phalee belonging to the family Tiliaceae having 50 genera and 450 species. is not among the studied medicinal agent despite its potential in ethnopharmacology. The present study investigated antioxidant, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-gluco...
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Published in | Pharmacognosy Magazine Vol. 13; no. 52; pp. 647 - 651 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
India
Medknow Publications & Media Pvt Ltd
01.10.2017
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Subjects | |
Online Access | Get full text |
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Summary: | (
) commonly known as Boa-phalee belonging to the family Tiliaceae having 50 genera and 450 species.
is not among the studied medicinal agent despite its potential in ethnopharmacology.
The present study investigated antioxidant, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase inhibitory activities of
. The dichloromethane and methanolic extracts of the
were evaluated for biological activities such as antioxidant and enzyme inhibitory activities of AChE, BChE, and α-glucosidase.
Antioxidant activity was evaluated by measuring free radical scavenging potential of
using 1,1-diphenyl-2-picrylhydrazyl. Enzyme inhibition activities were done by measuring optical density.
The methanol extract of roots of
showed potential free radical scavenging activity 99% at concentration 16.1 μg/ml. AChE was inhibited by aerial part of dichloromethane fraction by 46.07% ± 0.45% while dichloromethane extracts of roots of
possessed significant activity against BChE with 86% inhibition compared with standard drug Eserine at concentration 0.5 mg/ml. The dichloromethane extract of roots of
showed 79% inhibition against α-glucosidase enzyme activity with IC
62.8 ± 1.5 μg/ml.
These findings suggest
as useful therapeutic option as antioxidant and inhibition of AChE, BChE, and α-glucosidase activities.
The aerial parts and roots of
(
) were extracted in dichloromethane and methanolThe extract of roots of
showed free radical scavenging activity 99% at concentration 16.1 mg/ml, Ach inhibition by aerial parts of dichloromethane fraction by 46.07%, and 79% inhibition against a-glucosidase enzyme activity with IC
62.8 ± 1.5 mg/mlThe dichloromethane and methanolic extracts of
exhibited antioxidant inhibition of acetyl cholinesterase, butyrylcholinesterase, and a-glucosidase activities.
DPPH: 1,1-diphenyl-2-picrylhydrazyl,
:
, AChE: Acetylcholinesterase, BChE: Butyrylcholinesterase, AD: Alzheimer's disease. |
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ISSN: | 0973-1296 0976-4062 |
DOI: | 10.4103/pm.pm_95_17 |