Modulatory mechanisms of NLRP3: Potential roles in inflammasome activation

• Published in: Life sciences (1973) Vol. 267; p. 118918
• Main Authors: Ge, Qihui, Chen, Xinnong, Zhao, Yixuan, Mu, Huaiyu, Zhang, Junping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.02.2021; Elsevier BV
• Subjects: Animals; Chromosomes; Cytokines; Cytokines - metabolism; Deoxyribonucleic acid; DNA; Expression Regulation; Gene expression; Histone Modification; Humans; IL-1β; Immunity, Innate - immunology; Inflammasomes; Inflammasomes - metabolism; Inflammasomes - physiology; Inflammation; Inflammation - immunology; Interleukin 18; Localization; Macrophages - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - physiology; NLRP3; Non-coding RNAs; Post-transcription; Signal Transduction; Non-coding RNAs; NLRP3; Histone Modification; Expression Regulation
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2020.118918

The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studies have focused on specifically targeting NLRP3 to develop inhibitors against NLRP3 inflammasome. Here, we succinctly review the regulation of NLRP3 expression at DNA/chromosome, transcriptional, post-transcriptional, and translation levels. These are critical for the fine regulation of the NLRP3 inflammasome. [Display omitted]