Dimethyl sulfoxide-induced dehydration of the intermembrane space of dipalmitoylphosphatidylcholine multilamellar vesicles: Neutron and synchrotron diffraction study

Small-angle neutron scattering spectra of a polydispersed population of dipalmitoylphosphatidylcholine (DPPC) unilamellar vesicles in heavy water in the presence of dimethyl sulfoxide (DMSO) are analyzed by means of the separated form-factor method. An increase in the mole fraction of DMSO in water...

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Bibliographic Details
Published inCrystallography reports Vol. 62; no. 5; pp. 763 - 767
Main Authors Kiselev, M. A., Zemlyanaya, E. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2017
Springer Nature B.V
Subjects
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
Crystallography and Scattering Methods
DEHYDRATION
Dimethyl sulfoxide
Dipalmitoyl phosphatidylcholine
DISTANCE
DMSO
FORM FACTORS
HEAVY WATER
LAYERS
NEUTRON DIFFRACTION
Neutron scattering
Neutrons
Physics
Physics and Astronomy
SMALL ANGLE SCATTERING
SPECTRA
Sulfoxides
Surface
THICKNESS
Thin Films
Vesicles
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Summary:Small-angle neutron scattering spectra of a polydispersed population of dipalmitoylphosphatidylcholine (DPPC) unilamellar vesicles in heavy water in the presence of dimethyl sulfoxide (DMSO) are analyzed by means of the separated form-factor method. An increase in the mole fraction of DMSO in water from 0 to 15% was shown to lead to an increase in the thickness of the bilayer to the characteristics repeat distances of DPPC multilamellar membranes. This fact is indicative of dehydration of the intermembrane space and a steric contact between adjacent DPPC bilayers at 15% mole fraction of DMSO.
ISSN:1063-7745
1562-689X
DOI:10.1134/S106377451705011X