Recent advances in proton pump inhibitors and management of acid-peptic disorders

• Published in: Bioorganic & medicinal chemistry Vol. 15; no. 3; pp. 1181 - 1205
• Main Authors: Jain, Kishor S., Shah, Anamik K., Bariwal, Jitender, Shelke, Suhas M., Kale, Amol P., Jagtap, Jayshree R., Bhosale, Ashok V.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.2007; Elsevier Science
• Subjects: Acid pump antagonist (APAs); Acid-peptic disorders; Animals; Anti-Ulcer Agents - therapeutic use; Biological and medical sciences; Digestive system; Gastric Acid - secretion; Gastric H +/K +-ATPase (proton pump); Gastroesophageal Reflux - drug therapy; Helicobacter Infections - drug therapy; Humans; Medical sciences; Peptic Ulcer - drug therapy; Pharmacology. Drug treatments; Proton Pump Inhibitors; Proton pump inhibitors (PPIs); Therapeutic strategies; Acid-peptic disorders; Gastric H +/K +-ATPase (proton pump); Acid pump antagonist (APAs); Therapeutic strategies; Proton pump inhibitors (PPIs); Pathogenesis; Gastric H+/K+-ATPase (proton pump); Spirillaceae; H; Antiulcer agent; Review; K; Proton pump inhibitor; Cholinergic receptor; Helicobacter pylori; Structure activity relation; Antisecretory agent; Bacteria; Intestinal disease; Antagonist; Mechanism of action; Gastric disease; Spirillales; Enzyme; Enzyme inhibitor; Peptic ulcer; Chemotherapy; Treatment; Digestive diseases; Hydrolases; exchanging ATPase; Muscarinic receptor; Antibacterial agent; Antiacid; H2 Histamine receptor
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2006.07.068

Ongoing research work on proton pump inhibitors has also been covered. Acid-peptic ulcers and diseases have been increasingly on rise in today’s era of globalization, which is characterized by hurry, worry, and curry. This review summarizes various disorders associated with increased gastric acid secretion and various therapeutic strategies to control them. The emphasis has been laid, in particular, on the role of proton pump inhibitors (PPIs) widely used nowadays for the treatment of gastric acid diseases. The medicinal chemistry aspects and mechanism of action of irreversible PPIs and APAs have been discussed at molecular levels. The ongoing research status in this field has also been covered. Further, biological evaluation methods that can be used for screening of PPIs are also discussed in short.