Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population

• Published in: Medical science monitor Vol. 22; pp. 3828 - 3834
• Main Authors: Sun, Qin-Xiang, Zhou, Hai-Mei, Du, Qing-Wei
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 19.10.2016
• Subjects: Adult; Asian Continental Ancestry Group - genetics; Case-Control Studies; China; Clinical Research; Female; Furin - genetics; Furin - metabolism; Genetic Predisposition to Disease; Humans; Ischemic Attack, Transient - genetics; Ischemic Attack, Transient - metabolism; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Risk Factors
• ISSN: 1643-3750; 1234-1010; 1643-3750
• DOI: 10.12659/MSM.897122

BACKGROUND Because genotype CG/GG of Furin rs2071410 can increase susceptibility to hypertension, this study investigated whether Furin rs2071410 is correlated with transient ischemic attack (TIA) susceptibility and prognosis. MATERIAL AND METHODS The odds ratios (ORs) and their 95% confidence intervals (95% CIs) were evaluated to assess the association of rs2071410 with TIA risk, and logistic regression was used to estimate the effects of various risk factors (e.g., diabetes, hypertension, and hyperlipidemia) on TIA. RESULTS Compared with the homozygous genotype CC of rs2071410, the frequency of CG + GG genotype in the case group was significantly higher than in the control group (OR=1.47, 95% CI: 1.05-2.05, P<0.05). The CG + GG genotype carriers were observed to have worse 90-day prognosis after TIA treatment than patients carrying CC genotype (OR=12.86, 95% CI: 7.41-22.33, P<0.05). Moreover, logistic regression analysis found that age, diabetes, hypertension, and hyperlipidemia were associated with the onset of TIA (P<0.05, all). Of note, individuals with CG + GG genotype had 49.3% increased risk of TIA compared with individuals with CC genotype (OR=1.49, 95% CI: 1.05-2.12), and patients with CG + GG genotype had worse 90-day prognosis after TIA treatment than patients with CC genotype (OR=11.39, 95% CI: 6.29-20.62). CONCLUSIONS Furin rs2071410 was significantly correlated with TIA occurrence and prognosis in the Chinese population.