Role of energy metabolism in the preconditioned heart : a possible contribution of mitochondria

• Published in: Cardiovascular research Vol. 43; no. 1; pp. 32 - 43
• Main Authors: TAKEO, S, NASA, Y
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.1999
• Subjects: Adenosine - metabolism; Adenosine Triphosphate - metabolism; Animals; Biological and medical sciences; Cardiology. Vascular system; Coronary heart disease; Energy Metabolism - physiology; Glycolysis; Heart; Ischemic Preconditioning, Myocardial; Medical sciences; Mitochondria, Heart - metabolism; Myocardial Infarction - metabolism; Myocardium - metabolism; Potassium Channels - metabolism; Rats; Reactive Oxygen Species - metabolism; Energy metabolism; Pathophysiology; Enzyme; Adenosinetriphosphatase; Cardiovascular disease; Coronary heart disease; Myocardial disease; Vascular disease; Mitochondria; Ischemia; Animal; Myocardium; Hydrolases; Acidosis; Preconditioning
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1016/S0008-6363(99)00079-6

A brief period of ischemia and reperfusion has been shown to protect the myocardium against subsequent sustained ischemia and reperfusion injury, which is called "preconditioning". A great number of investigators have explored the mechanisms underlying this preconditioning-induced cardioprotection. This article dealt with possible mechanisms of energy metabolism and mitochondrial activity for preconditioning-induced cardioprotection. Particularly, the contribution of energy metabolites produced during a brief period of ischemia and reperfusion injury, as well as mitochondrial function that is modified by changes in mitochondrial ATPase activity, opening of mitochondrial ATP-dependent potassium channels and production of free radicals in mitochondria, to ischemic preconditioning is discussed.