Transmission dynamics of two dengue serotypes with vaccination scenarios

• Published in: Mathematical biosciences Vol. 287; pp. 54 - 71
• Main Authors: Morales, NL González, Núñez-López, M, Ramos-Castañeda, J, Velasco-Hernández, JX
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2017; Elsevier Science Ltd
• Subjects: Animals; Aquatic insects; Coexistence; Dengue; Dengue - immunology; Dengue - prevention & control; Dengue - transmission; Dengue fever; Dengue Vaccines; Dengue Virus - immunology; Disease transmission; Epidemiology; Humans; Immunity; Immunization; Mathematical models; Models, Theoretical; Mosquito Vectors; Outbreaks; Serogroup; Serotypes; Studies; Vaccination; Vaccine effects; Vector-borne diseases; Viral diseases; Serotypes; Vaccine effects; Dengue
• ISSN: 0025-5564; 1879-3134
• DOI: 10.1016/j.mbs.2016.10.001

•We consider a mathematical model with two viral strains and temporary cross-immunity with one vector mosquito population.•We study the impact of different vaccination strategies from the efficacy values of the vaccine, the transmission intensity and cross immunity periods.•We have varied the cross immunity periods (180 and 270 days) of both serotypes to study the effect of this parameter on the asymptotic dynamic of our model.•Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. In this work we present a mathematical model that incorporates two Dengue serotypes. The model has been constructed to study both the epidemiological trends of the disease and conditions that allow coexistence in competing strains under vaccination. We consider two viral strains and temporary cross-immunity with one vector mosquito population. Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. Indeed, vaccination and cross immunity period are seen to decrease the frequency and magnitude of outbreaks but in a differentiated manner with specific effects depending upon the interaction vaccine and strain type.