Rifampicin induced osteomalacia

A case of osteomalacia is reported in a patient on prolonged treatment with rifampicin for tuberculosis. It is suggested that rifampicin caused this complication by hepatic enzyme induction, an effect which is known to occur with anti-convulsant drug therapy. Les auteurs rapportent un cas d'ost...

Full description

Saved in:
Bibliographic Details
Published inTubercle Vol. 62; no. 3; pp. 207 - 209
Main Authors Shah, S.C., Sharma, R.K., Hemangini, Chitle, A.R.
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.09.1981
Subjects
Adult
Female
Humans
Osteomalacia - chemically induced
Rifampin - adverse effects
Rifampin - therapeutic use
Tuberculosis, Lymph Node - drug therapy
Online AccessGet full text

Cover

More Information
Summary:A case of osteomalacia is reported in a patient on prolonged treatment with rifampicin for tuberculosis. It is suggested that rifampicin caused this complication by hepatic enzyme induction, an effect which is known to occur with anti-convulsant drug therapy. Les auteurs rapportent un cas d'ostéomalacie chez un malade sous traitement prolongé par la rifampicine, pour tuberculose. On suppose que la rifampicine a entraîné cette complication par induction enzymatique hépatique, effet que l'on rencontre avec le traitement par les médicaments anticonvulsifs. Se informa sobre un caso de osteomalacia en un paciente en tratamiento prolongado con rifampicina a causa de una tuberculosis. Se sugiere la hipótesis de que la rifampicina produce esta complicación por induction enzimática hepática, efecto que es conocido en los tratamientos con medicamentos anti-convulsivantes.
ISSN:0041-3879
DOI:10.1016/0041-3879(81)90008-8