Highly NIR-emitting ytterbium complexes containing 2-(tosylaminobenzylidene)- N -benzoylhydrazone anions: structure in solution and use for bioimaging

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 50; no. 11; pp. 3786 - 3791
• Main Authors: Kovalenko, Anton D., Pavlov, Alexander A., Ustinovich, Ilya D., Kalyakina, Alena S., Goloveshkin, Alexander S., Marciniak, Łukasz, Lepnev, Leonid S., Burlov, Anatolii S., Schepers, Ute, Bräse, Stefan, Utochnikova, Valentina V.
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.03.2021
• Subjects: Anions; Crystal structure; Crystallography; Medical imaging; NMR spectroscopy; Toxicity; Ytterbium
• ISSN: 1477-9226; 1477-9234; 1477-9234
• DOI: 10.1039/D0DT03913F

Solution behaviour in DMSO using 1D and 2D NMR spectroscopy was performed for lanthanide complexes Ln(L)(HL) and Ln(HL) 2 Cl, containing non-macrocyclic 2-(tosylamino)-benzylidene- N -benzoylhydrazone (H 2 L), and the structure of [Yb(L)] + cation in solution was determined. Based on the NMR data, the possibility to obtain novel complexes containing [Ln(L) 2 ] − was predicted, which was successfully synthesized, and the crystal structure of K(C 2 H 5 OH) 3 [Yb(L) 2 ] was determined. Thanks to its high quantum yield of NIR luminescence (1.3 ± 0.2%), high absorption, low toxicity, and the stability of its anion against dissociation in DMSO, K(H 2 O) 3 [Yb(L) 2 ] was successfully used for bioimaging.