Protective effect of oral histidine on hypertension in Dahl salt-sensitive rats induced by high-salt diet

• Published in: Life sciences (1973) Vol. 270; p. 119134
• Main Authors: Yang, Pengfei, Zhao, Xinrui, Zhou, Luxin, Jin, Yuexin, Zheng, Xuewei, Ouyang, Yanan, Chen, Meng, Zeng, Li, Chen, Sa, Chen, Xiangbo, Tian, Zhongmin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.04.2021; Elsevier BV
• Subjects: Administration, Oral; Animals; Arginine; Blood pressure; Blood Pressure - drug effects; Cardiovascular diseases; Cardiovascular Diseases - metabolism; Dahl salt-sensitive rats; Damage patterns; Diet; Gas chromatography; Health risks; Histidine; Histidine - metabolism; Histidine - pharmacology; Hypertension; Hypertension - drug therapy; Hypertension - metabolism; Hypertension - physiopathology; Kidney - metabolism; Kidney damage; Kidney Diseases - metabolism; Kidneys; Male; Mass spectrometry; Mass spectroscopy; Metabolism; Metabolites; Nitric oxide; Nitric Oxide - metabolism; Nitrogen; Nitrogen metabolism; Pathway enrichment analysis; Rats; Rats, Inbred Dahl; Reactive oxygen species; Reactive Oxygen Species - metabolism; Risk analysis; Risk factors; Salt; Salts; Sodium; Sodium Chloride, Dietary - adverse effects; Hypertension; Pathway enrichment analysis; Dahl salt-sensitive rats; Histidine; Kidney damage
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2021.119134

Salt-sensitive hypertension is a risk factor for cardiovascular disease. Previous studies have shown that insufficient arginine in the kidney caused by metabolic imbalance is an important factor in salt-sensitive hypertension. Whether the high nitrogen content of histidine can affect the balance of nitrogen metabolism in Dahl salt-sensitive (SS) rats. This article aimed to study the effects of oral histidine on salt-sensitive hypertension, kidney damage and metabolic patterns of high-salt diet in SS rats. Adult rats were divided into four groups, and blood pressure was measured using a non-invasive tail-cuff system. Gas chromatography-mass spectrometry analyzed metabolites in serum and kidney tissues. High-salt diet significantly increased the blood pressure of rats and aggravated kidney damage. Of note, histidine can attenuate salt-sensitive hypertension and kidney damage by improving metabolic pattern, reducing Reactive Oxygen Species (ROS) and increasing nitric oxide levels in SS rats. These results suggest that histidine could be a potential adjuvant to prevent and control salt-sensitive hypertension. [Display omitted] •Salt sensitive rats developed salt-sensitive hypertension and renal injury under high salt.•Histidine significantly decreased ROS, increased nitric oxide level and altered the metabolic profile of SS rats.•Some amino acids metabolic pathways suggested a vital role in the antihypertension.•Histidine has prophylaxis function on salt-sensitive hypertension.