Protective effect of oral histidine on hypertension in Dahl salt-sensitive rats induced by high-salt diet
Salt-sensitive hypertension is a risk factor for cardiovascular disease. Previous studies have shown that insufficient arginine in the kidney caused by metabolic imbalance is an important factor in salt-sensitive hypertension. Whether the high nitrogen content of histidine can affect the balance of...
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Published in | Life sciences (1973) Vol. 270; p. 119134 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.04.2021
Elsevier BV |
Subjects | |
Online Access | Get full text |
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Summary: | Salt-sensitive hypertension is a risk factor for cardiovascular disease. Previous studies have shown that insufficient arginine in the kidney caused by metabolic imbalance is an important factor in salt-sensitive hypertension. Whether the high nitrogen content of histidine can affect the balance of nitrogen metabolism in Dahl salt-sensitive (SS) rats. This article aimed to study the effects of oral histidine on salt-sensitive hypertension, kidney damage and metabolic patterns of high-salt diet in SS rats.
Adult rats were divided into four groups, and blood pressure was measured using a non-invasive tail-cuff system. Gas chromatography-mass spectrometry analyzed metabolites in serum and kidney tissues.
High-salt diet significantly increased the blood pressure of rats and aggravated kidney damage. Of note, histidine can attenuate salt-sensitive hypertension and kidney damage by improving metabolic pattern, reducing Reactive Oxygen Species (ROS) and increasing nitric oxide levels in SS rats.
These results suggest that histidine could be a potential adjuvant to prevent and control salt-sensitive hypertension.
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•Salt sensitive rats developed salt-sensitive hypertension and renal injury under high salt.•Histidine significantly decreased ROS, increased nitric oxide level and altered the metabolic profile of SS rats.•Some amino acids metabolic pathways suggested a vital role in the antihypertension.•Histidine has prophylaxis function on salt-sensitive hypertension. |
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ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/j.lfs.2021.119134 |