A screening assay for detecting CD8 + cell non-cytotoxic anti-HIV responses

• Published in: Journal of immunological methods Vol. 304; no. 1; pp. 137 - 150
• Main Authors: Killian, M. Scott, Ng, Sharon, Mackewicz, Carl E., Levy, Jay A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2005; Elsevier
• Subjects: Antiviral; Assay; Biological and medical sciences; CD8 + lymphocyte; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; CNAR; Cytotoxicity, Immunologic; Enzyme-Linked Immunosorbent Assay - methods; Flow Cytometry - methods; Fundamental and applied biological sciences. Psychology; Fundamental immunology; HIV; HIV - immunology; HIV - physiology; HIV Infections - diagnosis; HIV Infections - immunology; HIV Infections - prevention & control; Humans; Immune response; Innate; Killer Cells, Natural - immunology; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - virology; Lymphocyte Count - methods; Lymphocyte Depletion; Mass Screening - methods; Microbiology; Molecular immunology; Techniques; Techniques used in virology; Virology; Virus Replication - physiology; Assay; CNAR; Immune response; HIV; CD8 + lymphocyte; Antiviral; Innate; Retroviridae; Lentivirus; Immunological method; Virus; CD8+ lymphocyte; Human immunodeficiency virus; Detection; Lymphocyte

The rate of HIV-1 disease progression is influenced by several factors that include pathogen and host genetic variations and the quality of antiviral immune responses. The CD8 + cell non-cytotoxic antiviral response (CNAR) substantially suppresses HIV replication in CD4 + cells and is positively ass...