Efficacy of ω-3 supplementation on nutritional status, skeletal muscle, and chemoradiotherapy toxicity in cervical cancer patients: A randomized, triple-blind, clinical trial conducted in a middle-income country

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 67-68; p. 110528
• Main Authors: Aredes, Mariah Azevedo, da Camara, Alex Oliveira, de Paula, Nathália Silva, Fraga, Karla Yasmin Dias, do Carmo, Maria das Graças Tavares, Chaves, Gabriela Villaça
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019; Elsevier Limited
• Subjects: Anthropometry; Body composition; Body weight; Cancer; Cervical cancer; Cervix; Chemoradiotherapy; Chemotherapy; Clinical trials; Computed tomography; Dietary supplements; Infiltration; Muscles; Musculoskeletal system; Nutritional status; Oils & fats; Olive oil; Patients; Population studies; Preservation; Quality; Radiation therapy; Randomization; Skeletal muscle; Toxicity; ω-3; Brazil; ω-3; Computed tomography; Cervical cancer; Body composition; Nutritional status; Skeletal muscle
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2019.06.009

•This was the first randomized controlled trial focusing on ω-3 supplementation in cervical cancer.•We used an innovative methodology for skeletal muscle quality assessment.•The results suggested a protective role of ω-3 in skeletal muscle quality.•Supplementation with ω-3 significantly reduced chemoradiotherapy toxicity. Supplementation with ω-3 has been shown to favor the preservation of body weight and skeletal muscle. The aim of this study was to evaluate the efficacy of ω-3 supplementation on nutritional status, skeletal muscle quantity and quality, and toxicity for treatment of women with cervical cancer. This was a randomized, triple-blinded, placebo-controlled clinical trial in women diagnosed with cervical cancer who underwent chemoradiotherapy between March 2016 and August 2017. The intervention group received four capsules with ω-3 (2.5 g/d) and the control group (CG) received the same number of identical-looking capsules with olive oil, for 45 d. Nutritional status was measured by anthropometry and Patient-Generated Subjective Global Assessment. Body composition was assessed by computed tomography. The skeletal muscle index was calculated using the range –29 to +150 HU. For skeletal muscle quality, the area comprised between –29 and +29 HU was denominated low-radiodensity skeletal muscle index and the range between +30 and +150 HU high-radiodensity skeletal muscle index, representing the skeletal muscle area with high or low intramuscular fat infiltration, respectively. The study population comprised 40 patients, with an average age 44.53 ± 8.73. The intervention group maintained body weight and showed an improvement in Patient-Generated Subjective Global Assessment score. A significant reduction in skeletal muscle index was observed in both groups. However, in regard to skeletal muscle quality, patients in the intervention group preserved low- and high-radiodensity skeletal muscle index, whereas those in the control group had increased low-radiodensity skeletal muscle index and significantly reduced high-radiodensity skeletal muscle index, reflecting high intramuscular fat infiltration only in the control group. The incidence of chemotherapy toxicity was significantly lower in the intervention group. The results suggest that ω-3 supplementation is effective in maintaining nutritional status, skeletal muscle quality, and reduced symptoms of chemoradiotherapy among women with cervical cancer.