Transendothelial migration (TEM) of in vitro generated dendritic cell vaccine in cancer immunotherapy

Many efforts have been made to improve the efficacy of dendritic cell (DC) vaccines in DC-based cancer immunotherapy. One of these efforts is to deliver a DC vaccine more efficiently to the regional lymph nodes (rLNs) to induce stronger anti-tumor immunity. Together with chemotaxis, transendothelial...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 42; no. 7; pp. 582 - 590
Main Authors Ashraf, Muhammad Umer, Jeong, Yideul, Roh, Seung-Eon, Bae, Yong-Soo
Format Journal Article
LanguageEnglish
Published Seoul Pharmaceutical Society of Korea 01.07.2019
대한약학회
Subjects
Animals
Cancer Vaccines - immunology
Dendritic Cells - immunology
Humans
Immunotherapy
Medicine
Neoplasms - immunology
Neoplasms - therapy
Pharmacology/Toxicology
Pharmacy
Review
Transendothelial and Transepithelial Migration - immunology
약학
DC vaccine
regional LNs
JAML
cancer immunotherapy
chemotaxis
JAMs
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Summary:Many efforts have been made to improve the efficacy of dendritic cell (DC) vaccines in DC-based cancer immunotherapy. One of these efforts is to deliver a DC vaccine more efficiently to the regional lymph nodes (rLNs) to induce stronger anti-tumor immunity. Together with chemotaxis, transendothelial migration (TEM) is believed to be a critical and indispensable step for DC vaccine migration to the rLNs after administration. However, the mechanism underlying the in vitro -generated DC TEM in DC-based cancer immunotherapy has been largely unknown. Currently, junctional adhesion molecules (JAMs) were found to play an important role in the TEM of in vitro generated DC vaccines. This paper reviews the TEM of DC vaccines and TEM-associated JAM molecules.
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http://link.springer.com/10.1007/s12272-019-01145-w
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-019-01145-w