Cord Gas Analysis, Decision-to-Delivery Interval, and the 30-Minute Rule for Emergency Cesareans

• Published in: Journal of Perinatology Vol. 25; no. 4; pp. 229 - 235
• Main Authors: Holcroft, Cynthia J, Graham, Ernest M, Aina-Mumuney, Abimbola, Rai, Karishma K, Henderson, Janice L, Penning, Donald H
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.04.2005
• Subjects: Acidosis; Acidosis - prevention & control; Analysis; Anesthesia; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Gas Analysis; Blood gases; Cerebral palsy; Cesarean section; Cesarean Section - standards; Cesarean Section - utilization; Cohort analysis; Decision analysis; Decision Making; Emergency Medical Services - standards; Female; Fetal Blood - chemistry; Fetal Diseases - prevention & control; Fetal heart rate monitoring; Fetal Monitoring; Fetuses; Gas analysis; Gases; Health aspects; Heart rate; Humans; Hypoxia; Medicine; Metabolic acidosis; Metabolism; Methods; Monitoring; Neonates; Neurological complications; Practice guidelines (Medicine); Pregnancy; Pregnancy Outcome; Retrospective Studies; Statistical analysis; Telemedicine; Time Factors; United States; United States > US; Baltimore Maryland
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/sj.jp.7211245

Our primary objective was to examine the relationship between umbilical arterial gas analysis and decision-to-delivery interval for emergency cesareans performed for nonreassuring fetal status to determine if this would validate the 30-minute rule. For this retrospective cohort study, all cesarean deliveries performed for nonreassuring fetal status from September 2001 to January 2003 were reviewed. A synopsis of clinical information that would have been available to the clinician at the time of delivery and the last hour of the electronic fetal heart rate tracing prior to delivery were reviewed by three different maternal-fetal medicine specialists masked to outcome, who classified each delivery as either emergent (delivery as soon as possible) or urgent (willing to wait up to 30 minutes for delivery) since immediacy of the fetal condition is the key factor affecting the type of anesthesia used. Of 145 cesareans performed for nonreassuring fetal status during this period, 117 patients met criteria for entry, of which 34 were classified as emergent and 83 as urgent. Kappa correlation was 0.35, showing only fair/moderate agreement between reviewers. In the emergent group, general anesthesia was more common (35.3%, 10.8%, p=0.003), and the decision-to-delivery interval was 14 minutes shorter (23.0+/-15.3, 36.7+/-14.9 minutes, p<0.001). Linear regression showed a statistically significant relationship between increasing decision-to-delivery interval and umbilical arterial pH (r=0.22, p=0.02) and base excess (r=0.33, p<0.001) showing that delivery proceeded sooner for most of those with the worst cord gases, with a gradual improvement over time. For the 13 (11%) neonates with cord gases placing them at increased risk for long-term neurologic sequelae, the decision-to-delivery interval was 24.7+/-14.6 minutes (range 6 to 50 minutes), and 3/13 (23%) were classified as urgent rather than emergent. Electronic fetal monitoring shows considerable variation in interpretation among maternal-fetal medicine specialists and is not a sensitive predictor of the fetus developing metabolic acidosis. There is no deterioration in cord gas results after 30 minutes, and most neonates delivered emergently or urgently for nonreassuring fetal status even when born after 30 minutes have normal cord gases. The 30-minute rule is a compromise that reflects the time it takes the fetus to develop severe metabolic acidosis, our imprecision in its identification, and its rarity in the presence of nonreassuring fetal monitoring.