Evaluation of angiopoietin-like protein 3 (ANGPTL3) levels in polycystic ovary syndrome

• Published in: Life sciences (1973) Vol. 263; p. 118595
• Main Authors: Vatannejad, Akram, Salimi, Fouzieh, Moradi, Nariman, Fouani, Fatima Zahraa, Zandieh, Zahra, Ansaripour, Soheila, Sadeghi, Asie, Fadaei, Reza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.12.2020; Elsevier BV
• Subjects: Adiponectin; Adiponectin - blood; Adult; Angiopoietin; Angiopoietin-Like Protein 3; Angiopoietin-like Proteins - blood; C-reactive protein; C-Reactive Protein - metabolism; Case-Control Studies; Correlation; Dyslipidemia; Dyslipidemias - etiology; Female; High density lipoprotein; Homocysteine; Homocysteine - blood; Humans; Insulin; Insulin - blood; Insulin Resistance; Lipid metabolism; Lipids; Ovaries; Pathogenesis; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - physiopathology; Proteins; Serum levels; Triglycerides; Polycystic ovary syndrome; Insulin resistance; Angiopoietin-like protein 3; Adiponectin
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2020.118595

Angiopoietin-like protein 3 (ANGPTL3) is recognized as a regulator of lipid metabolism. However, little is known about its association with insulin resistance in polycystic ovary syndrome (PCOS) setting. The present study aimed to investigate the serum levels of ANGPTL3 and adiponectin in PCOS women compared to healthy controls. In this study, a total of 175 premenopausal women (117 PCOS and 58 non-PCOS) were enrolled. Serum concentrations of ANGPTL3, adiponectin, fasting insulin, and other hormonal variables were measured using ELISA technique. Results showed that adiponectin levels were significantly lower in PCOS group than those of non-PCOS group. However, serum levels of ANGPTL3, high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) were found to be higher in PCOS patients, when compared to non-PCOS ones. Moreover, serum ANGPTL3 positively correlated with BMI and serum triglyceride, while it inversely correlated with serum HDL-C in PCOS patients. Our results demonstrated that increased levels of ANGPTL3 correlated with insulin resistance and dyslipidemia in PCOS patients, highlighting the need for future studies targeting its role in the pathogenesis of this disease. •Circulating levels of ANGPTL3 are elevated in PCOS patients.•ANGPTL3 is associated with insulin resistance in these patients.•ANGPTL3 might play a role in PCOS pathogenesis.