Chemical interconversion of T-2 and HT-2 toxins and related compounds

Mild alkaline hydrolysis of 3α-hydroxy-4β, 15-diacetoxy-8α-isovaleroxy-12,13-epoxytrichothec-9-ene (T-2 toxin) gave the 3α,4β-diol (HT-2 toxin) and the 3α,4β,15-triol as well as the 3α,4β,8α,15-tetraol. Partial acetylation of the diol gave mainly the 4β-hydroxy-3α-acetate, isomeric with T-2 toxin....

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 45; no. 2; pp. 396 - 401
Main Authors Wei, Ru-dong, Strong, F.M., Smalley, E.B., Schnoes, H.K.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.10.1971
Subjects
Acetates
Acylation
Ammonia
Anhydrides
Chemical Phenomena
Chemistry
Chromatography
Chromatography, Thin Layer
Fusarium
Fusarium tricinctum
Hydrolysis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mycotoxins - chemical synthesis
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Summary:Mild alkaline hydrolysis of 3α-hydroxy-4β, 15-diacetoxy-8α-isovaleroxy-12,13-epoxytrichothec-9-ene (T-2 toxin) gave the 3α,4β-diol (HT-2 toxin) and the 3α,4β,15-triol as well as the 3α,4β,8α,15-tetraol. Partial acetylation of the diol gave mainly the 4β-hydroxy-3α-acetate, isomeric with T-2 toxin.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(71)90832-1