Active site-directed protein regulation

• Published in: Nature (London) Vol. 402; no. 6760; pp. 373 - 376
• Main Authors: Kobe, Bostjan, Kemp, Bruce E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 25.11.1999; Nature Publishing Group
• Subjects: Allosteric Regulation; Analytical, structural and metabolic biochemistry; Anatomy & physiology; Binding Sites; Biological and medical sciences; Cellular biology; Endopeptidases - metabolism; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; General aspects, investigation methods; Models, Molecular; Protein Kinases - metabolism; Proteins; Proteins - metabolism; Substrate Specificity; Regulation(control); Enzymatic activity; Allosteric regulation; Enzyme; Active site; Allostery; Self regulation; Review; Mechanism of action; Intrasteric regulation; Intramolecular interaction; Protein

Regulation of protein function is vital for the control of cellular processes. Proteins are often regulated by allosteric mechanisms, in which effectors bind to regulatory sites distinct from the active sites and alter protein function. Intrasteric regulation, directed at the active site and thus th...