Active site-directed protein regulation

Regulation of protein function is vital for the control of cellular processes. Proteins are often regulated by allosteric mechanisms, in which effectors bind to regulatory sites distinct from the active sites and alter protein function. Intrasteric regulation, directed at the active site and thus th...

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Bibliographic Details
Published inNature (London) Vol. 402; no. 6760; pp. 373 - 376
Main Authors Kobe, Bostjan, Kemp, Bruce E
Format Journal Article
LanguageEnglish
Published London Nature Publishing 25.11.1999
Nature Publishing Group
Subjects
Allosteric Regulation
Analytical, structural and metabolic biochemistry
Anatomy & physiology
Binding Sites
Biological and medical sciences
Cellular biology
Endopeptidases - metabolism
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Models, Molecular
Protein Kinases - metabolism
Proteins
Proteins - metabolism
Substrate Specificity
Regulation(control)
Enzymatic activity
Allosteric regulation
Enzyme
Active site
Allostery
Self regulation
Review
Mechanism of action
Intrasteric regulation
Intramolecular interaction
Protein
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Summary:Regulation of protein function is vital for the control of cellular processes. Proteins are often regulated by allosteric mechanisms, in which effectors bind to regulatory sites distinct from the active sites and alter protein function. Intrasteric regulation, directed at the active site and thus the counterpart of allosteric control, is now emerging as an important regulatory mechanism.
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ISSN:0028-0836
1476-4687
DOI:10.1038/46478