MAP Kinases: From Intracellular Signals to Physiology and Disease

Herbert Schramek Department of Physiology, University of Innsbruck, A-6010 Innsbruck, Austria Although differentiated cells will usually maintain their specialized character, conversion of cellular specificities can be observed during adaptation or reparative regeneration. In pathological conditions...

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Bibliographic Details
Published inNews in physiological sciences Vol. 17; no. 2; pp. 62 - 67
Main Author Schramek, Herbert
Format Journal Article
LanguageEnglish
Published United States Am Physiological Soc 01.04.2002
Subjects
Humans
Inflammation - metabolism
MAP Kinase Signaling System - physiology
Neoplasms - metabolism
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Summary:Herbert Schramek Department of Physiology, University of Innsbruck, A-6010 Innsbruck, Austria Although differentiated cells will usually maintain their specialized character, conversion of cellular specificities can be observed during adaptation or reparative regeneration. In pathological conditions, such as inflammation and carcinogenesis, even highly specialized cells can alter their properties, leading to a deranged control of cell differentiation and/or proliferation. Mitogen-activated protein kinases are central regulators of these processes.
ISSN:1548-9213
0886-1714
1548-9221
DOI:10.1152/nips.01365.2001