Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice

• Published in: Cardiovascular research Vol. 50; no. 3; pp. 516 - 524
• Main Authors: PALMEN, M, DAEMEN, M. J. A. P, BRONSAER, R, DASSEN, W. R. M, ZANDBERGEN, H. R, KOCKX, M, SMITS, J. F. M, VAN DER ZEE, R, DOEVENDANS, P. A
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2001
• Subjects: Animals; Apoptosis; Biological and medical sciences; Body Weight - physiology; Capillaries - pathology; Cardiology. Vascular system; Coronary heart disease; Coronary Vessels - pathology; DNA - biosynthesis; Female; Heart; Insulin-Like Growth Factor I - deficiency; Insulin-Like Growth Factor I - physiology; Male; Medical sciences; Mice; Mice, Inbred C57BL; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Organ Size - physiology; Ventricular Function, Left - physiology; Ventricular Remodeling - physiology; Heart; Prognosis; Infarct; Pathogenesis; Rodentia; Cardiovascular disease; Insulin like growth factor 1; Coronary heart disease; Myocardial disease; Vascular remodeling; Vertebrata; Mammalia; Mouse; Animal; Myocardium
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1016/S0008-6363(01)00237-1

To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function. A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured. No significant difference in cardiac function was found between infarcted wildtype and knock-out animals, despite a marked reduction in capillarization and blunting of the hypertrophic response of the interventricular septum in the IGF-1 deficient group. Furthermore, decreased DNA synthesis and increased apoptosis rates were observed in the IGF-1 knock-out mice. IGF-1 deficient mice show preservation of cardiac function 1 week after MI, despite an altered cardiac remodeling process.