Irrelevance of USF2 rs916145 polymorphism with the risk of biliary atresia susceptibility in Southern Chinese children

Biliary atresia (BA) is a very rare neonatal disease, however, it has been the most common cause of obstructive jaundice in infancy. The complex pathogenesis of BA is not entirely clear and a lot of possible pathogenic mechanisms have been proposed to explain the etiology of BA, including genetic, i...

Full description

Saved in:
Bibliographic Details
Published inBioscience reports Vol. 40; no. 2
Main Authors Chen, Lei, Fu, Ming, Tan, Ledong, Zhao, Jinglu, Xu, Xiaogang, Lin, Yuzhen, Zhong, Qian, Zhong, Ruisui, Zhang, RuiZhong, Zeng, Jixiao
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 28.02.2020
Subjects
Age Factors
Biliary Atresia - diagnosis
Biliary Atresia - genetics
Bioinformatics
Case-Control Studies
China
DNA, Chromosomes & Chromosomal Structure
Epigenetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genomics
Heterozygote
Homozygote
Humans
Infant
Male
Phenotype
Polymorphism, Single Nucleotide
Risk Assessment
Risk Factors
Upstream Stimulatory Factors - genetics
China
Risk
Biliary Atresia
USF2
Case-control
Polymorphism
Online AccessGet full text

Cover

More Information
Summary:Biliary atresia (BA) is a very rare neonatal disease, however, it has been the most common cause of obstructive jaundice in infancy. The complex pathogenesis of BA is not entirely clear and a lot of possible pathogenic mechanisms have been proposed to explain the etiology of BA, including genetic, inflammatory, environmental and developmental abnormalities. As a transcription factor, USF2 gene rs916145 polymorphism has been shown to be related to the risk of BA. We examined the USF2 rs916145 genotype in a large case-control study consisting of 506 BA patients and 1473 healthy controls, using the MassARRAY iPLEX Gold system (Sequenom). Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association between the USF2 gene rs916145 polymorphism and BA susceptibility. The frequency of different genotypes showed no statistical significance (GG/GC, OR: 1.09, P=0.470, 95% CI: 0.87-1.35; GG/CC, OR: 0.86, P=0.378, 95% CI: 0.62-1.20). No obvious association was revealed between the USF2 gene rs916145 polymorphism and BA susceptibility. USF2 rs916145 polymorphism may not be the best predictor of BA.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20193623