One-pot tandem cyclisation to pyrrolo[1,2-a][1,4]benzodiazepines: a modified approach to the Pictet-Spengler reaction

We have reported a one-pot two-step methodology for the synthesis of highly condensed heterocycles, pyrrolo[1,2-a][1,4] benzodiazepines, by a modified Pictet-Spengler reaction under mild conditions in a short time. Our approach has a few advantages over the conventional two components synthesis as i...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 17; no. 18; pp. 4652 - 4662
Main Authors Ali, Sk Asraf, Mondal, Suresh Kumar, Das, Tapas, Manna, Susanta Kumar, Bera, Anirban, Dafadar, Debabrata, Naskar, Sourenjit, Molla, Mijanur Rahaman, Samanta, Shubhankar
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2019
Royal Society of Chemistry
Subjects
Atom economy
Benzodiazepines
Chemistry
Chemistry, Organic
Crystallography
Physical Sciences
Science & Technology
Substrates
Synthesis
ATOM ECONOMY
HETEROCYCLES
PYRROLE
EFFICIENT SYNTHESIS
CATALYST
FACILE
DERIVATIVES
Online AccessGet full text

Cover

More Information
Summary:We have reported a one-pot two-step methodology for the synthesis of highly condensed heterocycles, pyrrolo[1,2-a][1,4] benzodiazepines, by a modified Pictet-Spengler reaction under mild conditions in a short time. Our approach has a few advantages over the conventional two components synthesis as it is step and atom economic, environmentally benign and a convergent synthetic method. We have discussed here the broad substrate scope of this novel methodology.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob00448c