Vestibular nuclear infarction: Case series and review of the literature

• Published in: Journal of stroke and cerebrovascular diseases Vol. 29; no. 8; p. 104937
• Main Authors: Ataç, Ceyla, Kısabay, Ayşın, Çetin Akkoç, Ceren, Saruhan, Gülsüm, Çelebisoy, Neşe
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.08.2020
• Subjects: Acute vestibular syndrome; Diffusion-weighted magnetic resonance images; HINTS battery; Vestibular nuclear infaction; Diffusion-weighted magnetic resonance images; Acute vestibular syndrome; HINTS battery; Vestibular nuclear infaction
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2020.104937

Acute vestibular syndrome (AVS) is a common cause of emergency admittance and has very rarely been reported due to a vestibular nucleus infarction. Initial magnetic resonance imaging studies (MRIs) including diffusion-weighted images may reveal normal results and even bedside examination tests like HINTS battery which involves head impulse test (HIT), nystagmus and test of skew can be challenging in differing a peripheral vestibulopathy from a central lesion. Four patients seen in the emergency department with AVS and evaluated with HINTS battery, cervical vestibular-evoked myogenic potentials (cVEMP) and cranial MRI revealing infarcts restricted to vestibular nuclei were evaluated. In two patients spontaneous nystagmus beating towards the unaffected side was present. In one patient spontaneous nystagmus changed direction on looking to the affected side. In the fourth gaze evoked nystagmus was present without any spontaneous nystagmus. In all, HIT was positive to the affected side. In three cVEMPs was studied revealing delayed latency, reduced amplitude p13/n23 potentials on the lesioned side in two of them. Initial MRIs including diffusion-weighted images disclosed acute infarction in the area of the vestibular nuclei in two patients, with normal results in the other two. Follow-up MRI's performed 48 hours later revealed vestibular nuclear infarction. It is not always easy to differentiate small lesions restricted to central vestibular structures from peripheral vestibular lesions both on clinical and radiological grounds. Follow-up cranial MRI is necessary in patients with known vascular risk factors.