Exploring the potential role of phase angle as a marker of oxidative stress: A narrative review

Chronic conditions including non-communicable diseases have become increasingly prevalent in the past decade. Proinflammatory cytokines are associated with the development of several pathologies, their prognoses, and their associated mortality. Chronic inflammation is also associated with oxidative...

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Published inNutrition (Burbank, Los Angeles County, Calif.) Vol. 93; p. 111493
Main Authors da Silva, Bruna Ramos, Gonzalez, Maria Cristina, Cereda, Emanuele, Prado, Carla M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2022
Elsevier Limited
Subjects
Antioxidants
Apoptosis
Bioelectrical impedance analysis
Bioelectricity
Biomarkers
Body Composition
Body mass index
Chronic conditions
Chronic illnesses
Cross-Sectional Studies
Cytokines
Diabetes
Disease
Electric currents
Electric Impedance
Free radicals
Homeostasis
Hydration
Inflammation
Lipid peroxidation
Lipids
Malnutrition
Markers
Metabolism
Metabolites
Mortality
Natural language processing
Oxidative Stress
Phase angle
Phase shift
Reactive oxygen species
Sarcopenia
Oxidative stress
Bioelectrical impedance analysis
Inflammation
Phase angle
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Summary:Chronic conditions including non-communicable diseases have become increasingly prevalent in the past decade. Proinflammatory cytokines are associated with the development of several pathologies, their prognoses, and their associated mortality. Chronic inflammation is also associated with oxidative stress whereby reactive oxygen species (ROS) induce cellular injury and, thus, by doing so, initiate inflammatory signaling. Phase angle (PhA) is a measurable body composition parameter obtained using bioelectrical impedance analysis (BIA). PhA is considered an indicator of cellular health and integrity and is also related to inflammatory markers and inflammation. Given the association among oxidative stress, cell damage, and inflammation that may in turn be associated with low PhA values, it is expected that PhA could mirror oxidative stress. In this hypothesis-generating, narrative review we summarize the current knowledge regarding the potential relationship between PhA and oxidative stress and their interrelationship in chronic conditions.
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ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2021.111493