Local Ablation Versus Surgical Resection for Liver Hemangioma: a Systematic Review and Meta-analysis

Surgical resection (SR) is the standard treatment for liver hemangioma (LH). Local ablation (LA) is a promising alternative treatment. This meta-analysis was conducted to compare the effectiveness and safety of LA in LH treatment. Clinical studies were retrieved from PubMed, Embase, Cochrane Library...

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Bibliographic Details
Published inIndian journal of surgery Vol. 83; no. 2; pp. 403 - 410
Main Authors He, Pan, Zhong, Furui, Su, Song, Fang, Cheng, Li, Bo, Xia, Xianming
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 01.04.2021
Springer
Springer Nature B.V
Subjects
Ablation
Ablation (Surgery)
Analysis
Cardiac Surgery
Care and treatment
Hemangioma
Liver
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Meta-analysis
Neurosurgery
Pediatric Surgery
Plastic Surgery
Review Article
Surgery
Systematic review
Thoracic Surgery
Thermal ablation
Liver hemangioma
Hepatectomy
Meta-analysis
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Summary:Surgical resection (SR) is the standard treatment for liver hemangioma (LH). Local ablation (LA) is a promising alternative treatment. This meta-analysis was conducted to compare the effectiveness and safety of LA in LH treatment. Clinical studies were retrieved from PubMed, Embase, Cochrane Library, Medline, and Web of Science electronic databases. Study-specific effect sizes and their 95% confidence intervals (CI) were combined to calculate the pooled value, using a fixed-effects or random effect model. Five studies were included. Major operation time (mean difference [MD] = − 121.17; 95% CI = − 155.38 – − 86.97), blood loss (MD = − 257.11; 95% CI = − 312.65 – − 201.58), hospital stay (MD = − 2.83; 95% CI = − 4.71 – − 0.94), and postoperative pain score after 12 h (MD = − 1.77; 95% CI = − 2.15 – − 1.39), 24 h (MD = −0.93; 95% CI = − 1.22 – − 0.65), and 48 h (MD = − 0.64; 95% CI = − 0.95 – − 0.33) were all lower in the LA group compared with the SR group. However, higher ALT (MD = 75.62; 95% CI = 23.99–127.25) and AST (MD = 129.92; 95% CI = 44.56–215.29) values were found in the LA group 1 day after the surgery. This systematic review shows the superiority of LA over SR in terms of effectiveness and safety in LH treatment.
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-020-02234-7