Distinct light microscopic changes in human immunodeficiency virus-associated nemaline myopathy

The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however,...

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Published inNeurology Vol. 50; no. 2; p. 529
Main Authors Feinberg, D M, Spiro, A J, Weidenheim, K M
Format Journal Article
LanguageEnglish
Published United States 01.02.1998
Subjects
Adolescent
Adult
Biopsy
Child
Child, Preschool
Databases as Topic
Diagnosis, Differential
Female
HIV Infections - complications
HIV Infections - pathology
Humans
Infant
Male
Middle Aged
Muscle, Skeletal - pathology
Myopathies, Nemaline - etiology
Myopathies, Nemaline - pathology
Myopathies, Nemaline - physiopathology
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Summary:The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.
ISSN:0028-3878
DOI:10.1212/wnl.50.2.529