A simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature

A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature...

Full description

Saved in:
Bibliographic Details
Published inGreen chemistry letters and reviews Vol. 7; no. 3; pp. 228 - 235
Main Authors Desai, Uday V., Kulkarni, Makarand A., Pandit, Kapil S., Kulkarni, Aparna M., Wadgaonkar, Prakash P.
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 03.07.2014
Taylor & Francis Ltd
Subjects
diethylamine
Green chemistry
multicomponent reactions
organocatalyst
pyridine-3,5-dicarbonitriles
Temperature
Online AccessGet full text

Cover

More Information
Summary:A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for "green synthesis."
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2014.925144