A Convenient Procedure for the Synthesis of 2,2,2-Trifluoroethyl Methyl 2-Oxoalkylphosphonates
A convenient and versatile method was developed for the synthesis of 2,2,2-trifluoroethyl methyl 2-oxoalkylphosphonates starting from dimethyl phosphonates by alkaline hydrolysis followed by esterification with 2,2,2-trifluoroethanol using diisopropylcarbodiimide (DIC) in the presence of 4-(dimethyl...
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Published in | Phosphorus, sulfur, and silicon and the related elements Vol. 190; no. 5-6; pp. 677 - 680 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
ABINGDON
Taylor & Francis
03.06.2015
Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | A convenient and versatile method was developed for the synthesis of 2,2,2-trifluoroethyl methyl 2-oxoalkylphosphonates starting from dimethyl phosphonates by alkaline hydrolysis followed by esterification with 2,2,2-trifluoroethanol using diisopropylcarbodiimide (DIC) in the presence of 4-(dimethylamino)pyridine (DMAP) catalyst following the Steglich protocol. |
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ISSN: | 1042-6507 1563-5325 |
DOI: | 10.1080/10426507.2014.978326 |