A Convenient Procedure for the Synthesis of 2,2,2-Trifluoroethyl Methyl 2-Oxoalkylphosphonates

A convenient and versatile method was developed for the synthesis of 2,2,2-trifluoroethyl methyl 2-oxoalkylphosphonates starting from dimethyl phosphonates by alkaline hydrolysis followed by esterification with 2,2,2-trifluoroethanol using diisopropylcarbodiimide (DIC) in the presence of 4-(dimethyl...

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Bibliographic Details
Published inPhosphorus, sulfur, and silicon and the related elements Vol. 190; no. 5-6; pp. 677 - 680
Main Authors Molnár, Katalin, Behra, Julien, Takács, László, Kádár, Mihály, Kardos, Zsuzsanna, Faigl, Ferenc
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 03.06.2015
Taylor & Francis Ltd
Subjects
2,2,2-trifluoroethanol
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
methyl phosphonic acid
mixed phosphonoester
Physical Sciences
Science & Technology
Steglich protocol
Trifluoroethyl ester
Trifluoroethyl ester
mixed phosphonoester
Steglich protocol
2,2,2-trifluoroethanol
methyl phosphonic acid
ESTERS
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Summary:A convenient and versatile method was developed for the synthesis of 2,2,2-trifluoroethyl methyl 2-oxoalkylphosphonates starting from dimethyl phosphonates by alkaline hydrolysis followed by esterification with 2,2,2-trifluoroethanol using diisopropylcarbodiimide (DIC) in the presence of 4-(dimethylamino)pyridine (DMAP) catalyst following the Steglich protocol.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2014.978326