Bioinformatic gene analysis for potential biomarkers and therapeutic targets of diabetic nephropathy associated renal cell carcinoma
Numerous epidemiological studies have confirmed that diabetes can promote the development of malignant tumors. However, the relationship between renal cell carcinoma (RCC) and diabetic nephropathy (DN) is still controversial. This study aimed to investigate the genes that are co-expressed in DN and...
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Published in | Translational andrology and urology Vol. 9; no. 6; pp. 2555 - 2571 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
China
AME Publishing Company
01.12.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Numerous epidemiological studies have confirmed that diabetes can promote the development of malignant tumors. However, the relationship between renal cell carcinoma (RCC) and diabetic nephropathy (DN) is still controversial. This study aimed to investigate the genes that are co-expressed in DN and RCC in order to gain a better understanding of the relationship between these diseases, and to identify potential biomarkers and targets for the treatment of DN-related RCC.
We evaluated the differentially expressed genes (DEGs) that are co-expressed in DN and RCC using a wide range of target prediction and analysis methods. Twenty-four genes were identified by intersecting the differential genes of 3 DN datasets and 2 RCC datasets. We predicted the micro-ribonucleic acids (miRNAs) of these genes that may be controlled using the miRNA Data Integration Portal (mirDIP) database, and rated them according to each data forecast based on the Comparative Toxicogenomics Database (CTD) and the StarBase database.
Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (
); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (
); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (
); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucose-6-phosphatase catalytic subunit (
). These genes may serve as potential biomarkers or specific targets in the treatment of DN-related RCC.
A significant correlation was identified between DN and RCC. The
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genes could be novel biomarkers of DN-related RCC. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributions: (I) Conception and design: W Zhai, Y Xu; (II) Administrative support: Y Xu; (III) Provision of study materials or patients: Y Dong; (IV) Collection and assembly of data: Y Dong; (V) Data analysis and interpretation: Y Dong; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. |
ISSN: | 2223-4691 2223-4683 2223-4691 |
DOI: | 10.21037/tau-19-911 |