Physiologic analysis of the myoclonus of Alzheimer's disease

Ten patients with clinically diagnosed Alzheimer's disease, including three cases of trisomy 21 (Down's syndrome), developed a chronic myoclonic disorder. The technique of jerk-locked averaging of EEG activity was used to analyze the myoclonus. Seven subjects demonstrated a focal, contrala...

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Bibliographic Details
Published inNeurology Vol. 34; no. 7; p. 898
Main Authors Wilkins, D E, Hallett, M, Berardelli, A, Walshe, T, Alvarez, N
Format Journal Article
LanguageEnglish
Published United States 01.07.1984
Subjects
Aged
Alzheimer Disease - physiopathology
Down Syndrome - complications
Down Syndrome - physiopathology
Electroencephalography
Female
Humans
Male
Middle Aged
Myoclonus - complications
Myoclonus - physiopathology
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Summary:Ten patients with clinically diagnosed Alzheimer's disease, including three cases of trisomy 21 (Down's syndrome), developed a chronic myoclonic disorder. The technique of jerk-locked averaging of EEG activity was used to analyze the myoclonus. Seven subjects demonstrated a focal, contralateral central, negative cerebral potential antecedent to the myoclonic jerks. This EEG event differs from that previously reported to be associated with the myoclonus of subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).
ISSN:0028-3878
DOI:10.1212/wnl.34.7.898