Serine insertion caused by the ribosomal suppressor SUP46 in yeast

The ribosomal suppressor SUP46 isolated from the yeast Saccharomyces cerevisiae suppresses a broad range of mutations, including at least some UAA, UAG and UGA alleles. The SUP46 suppressor causes the insertion of serine into iso-1-cytochrome c at the site of the UAA mutation in the cyc1-72 allele....

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Bibliographic Details
Published inJournal of molecular biology Vol. 147; no. 3; pp. 373 - 379
Main Authors Ono, Bun-Ichiro, Stewart, John W., Sherman, Fred
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.04.1981
Subjects
Chromosome Mapping
Cytochrome c Group - biosynthesis
Genes, Dominant
Genetic Markers
Mutation
Ribosomes
RNA, Fungal
RNA, Transfer
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Serine - metabolism
Suppression, Genetic
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Summary:The ribosomal suppressor SUP46 isolated from the yeast Saccharomyces cerevisiae suppresses a broad range of mutations, including at least some UAA, UAG and UGA alleles. The SUP46 suppressor causes the insertion of serine into iso-1-cytochrome c at the site of the UAA mutation in the cyc1-72 allele. It is believed that the altered ribosomes in the SUP46 suppressor allow a serine tRNA to misread UAA codons.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-2836
1089-8638
DOI:10.1016/0022-2836(81)90489-7