Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling. The chiral-bridged biphenyl monophosphine ligand L1 was found to be much more effective in the reaction enantioselection than its counterpa...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 17; no. 9; pp. 2351 - 2355
Main Authors Xia, Wang, Zhang, Zhen-Wei, Li, Yongsu, Jiang, Xiaoding, Liang, Hao, Zhang, Yaqi, Cao, Rihui, Qiu, Liqin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2019
Royal Society of Chemistry
Subjects
Biphenyl
Chemistry
Chemistry, Organic
Cross coupling
Enantiomers
Ligands
Physical Sciences
Science & Technology
ATROPISOMERIC MONOPHOSPHINE LIGANDS
EFFICIENT SYNTHESIS
1ST
DIASTEREOSELECTIVE SYNTHESIS
ARYL CHLORIDES
Online AccessGet full text

Cover

More Information
Summary:A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling. The chiral-bridged biphenyl monophosphine ligand L1 was found to be much more effective in the reaction enantioselection than its counterpart binaphthyl monophosphine ligands.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/C8OB03048K