Principles and applications of nanomaterial-based hyperthermia in cancer therapy

Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and invasiveness and to maximize therapeutic efficacy. The high temperature of HTT induces pro...

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Published inArchives of pharmacal research Vol. 43; no. 1; pp. 46 - 57
Main Authors Kang, Jin Kook, Kim, Jae Chang, Shin, Yuseon, Han, Sang Myung, Won, Woong Roeck, Her, Jaewon, Park, June Yong, Oh, Kyung Taek
Format Journal Article
LanguageEnglish
Published Seoul Pharmaceutical Society of Korea 2020
대한약학회
Subjects
Medicine
Pharmacology/Toxicology
Pharmacy
Review
약학
SPIO
Hyperthermia
Cancer therapy
Nanotechnology
Gold nanoparticle
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Summary:Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and invasiveness and to maximize therapeutic efficacy. The high temperature of HTT induces protein denaturation that leads to apoptosis or necrosis. It can also enhance the effects of other cancer therapies because heat-damaged tissues reduce radioresistance and help accumulate anticancer drugs. Gold nanoparticles and superparamagnetic iron oxide with different energy sources are commonly used as hyperthermia agents. New types of nanoparticles such as those whose surface is coated with several polymers and those modified with targeting moieties have been studied as novel HTT agents. In this review, we introduce principles and applications of nanotechnology-based HTT using gold nanoparticles and superparamagnetic iron oxide.
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https://doi.org/10.1007/s12272-020-01206-5
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-020-01206-5