Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats

ABSTRACT Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC0-24 of DIOSG-CD, prepared by reacting DSN and nari...

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Published inBioscience, biotechnology, and biochemistry Vol. 87; no. 7; pp. 771 - 776
Main Authors Moriwaki, Masamitsu, Kito, Kento, Nakagawa, Ryo, Kapoor, Mahendra P, Matsumiya, Yoshiki, Fukuhara, Tomohisa, Kobayashi, Junya, Satomoto, Kensuke, Yamagata, Hiroshi, Kuroiwa, Yuichi
Format Journal Article
LanguageEnglish
Published England Oxford University Press 23.06.2023
Subjects
diosmetin-7-glucoside-γ-cyclodextrin
naringinase
chronic venous insufficiency
diosmin
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Summary:ABSTRACT Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC0-24 of DIOSG-CD, prepared by reacting DSN and naringinase with γ-CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats.
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ISSN:1347-6947
1347-6947
DOI:10.1093/bbb/zbad051