Wheel Running Simultaneously Induces CTA and Facilitates Feeding in Non-deprived Rats

• Published in: Appetite Vol. 31; no. 3; pp. 351 - 360
• Main Authors: LETT, B.T., GRANT, V.L., GABORKO, L.L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.12.1998; Elsevier
• Subjects: Biological and medical sciences; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Appetite; Physical exercise; Feeding behavior; Rat; Rodentia; Classical conditioning; Feeding; Alimentary aversion; Learning; Vertebrata; Mammalia; Acquisition process; Running-wheel; Gustation; Taste; Conditioned aversion
• ISSN: 0195-6663; 1095-8304
• DOI: 10.1006/appe.1998.0171

Previous findings indicate that wheel running can have either an aversive or an appetitive effect. That is, wheel running for 30 min induces conditioned taste aversion (CTA) in rats trained while hungry and thirsty but facilitates feeding in non-deprived rats. In Experiment 1, wheel running was also found to be effective in producing CTA in non-deprived rats. Therefore, Experiment 2 tested whether wheel running produces the aversive and appetitive effects simultaneously. During each of four training trials, two groups of non-deprived rats were given a flavored solution to drink for 10 min. Then those in the wheel group were put in running wheels for 30 min whereas those in the cage group spent 30 min in small cages. Finally, all rats were given a 60-min feeding test. After the first trial, the wheel group drank less flavored solution than the cage group during each of the remaining trials. The wheel group also ate more than the cage group on each feeding test. These results indicate that wheel running produces CTA and facilitates eating at the same time. A role for the mesolimbic dopamine reward system in these effects was considered.