The Sialoglycan Binding Adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae

Mycoplasma genitalium (Mge) and Mycoplasma pneumoniae (Mpn) are two human pathogens associated with urogenital and respiratory tract infections, respectively. The recent elucidation of the tridimensional structure of their major cytoadhesins by X-ray crystallography and cryo-electron microscopy/tomo...

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Published inTrends in microbiology (Regular ed.) Vol. 29; no. 6; pp. 477 - 481
Main Authors Vizarraga, David, Torres-Puig, Sergi, Aparicio, David, Pich, Oscar Q.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2021
Elsevier Science Ltd
Subjects
Adhesins
antigenic variation
bacterial cytoadhesins
Crystallography
Electron microscopy
Immunosurveillance
Infections
Mycoplasma genitalium
Mycoplasma pneumoniae
protein structure
receptor binding
Respiratory tract
Respiratory tract diseases
X-ray crystallography
protein structure
receptor binding
antigenic variation
bacterial cytoadhesins
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Summary:Mycoplasma genitalium (Mge) and Mycoplasma pneumoniae (Mpn) are two human pathogens associated with urogenital and respiratory tract infections, respectively. The recent elucidation of the tridimensional structure of their major cytoadhesins by X-ray crystallography and cryo-electron microscopy/tomography, has provided important insights regarding the mechanics of infection and evasion of immune surveillance.
Bibliography:ObjectType-Article-1
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ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2021.01.011