The Combined Usefulness of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Predicting Intravenous Immunoglobulin Resistance with Kawasaki Disease

The laboratory records of 405 patients with Kawasaki disease before and after intravenous immunoglobulin (IVIG) therapy were compared between the IVIG-responsive (n = 320) and IVIG-resistant (n = 85) groups. A high neutrophil-to-lymphocyte ratio and a high platelet-to-lymphocyte ratio before IVIG, e...

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Published inThe Journal of pediatrics Vol. 178; pp. 281 - 284.e1
Main Authors Kawamura, Yoichi, Takeshita, Seiichiro, Kanai, Takashi, Yoshida, Yusuke, Nonoyama, Shigeaki
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2016
Subjects
Blood Cell Count - methods
Blood Platelets - cytology
Child, Preschool
coronary artery abnormality
Drug Resistance
Female
Humans
Immunoglobulins, Intravenous - therapeutic use
Infant
Lymphocytes - cytology
Male
Mucocutaneous Lymph Node Syndrome - blood
Mucocutaneous Lymph Node Syndrome - drug therapy
Neutrophils - cytology
Pediatrics
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
white blood cell
white blood cell
NLR
PLR
IVIG
KD
coronary artery abnormality
CAAs
Platelet-to-lymphocyte ratio
Coronary artery abnormalities
Kawasaki disease
Neutrophil-to-lymphocyte ratio
Intravenous immunoglobulin
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Summary:The laboratory records of 405 patients with Kawasaki disease before and after intravenous immunoglobulin (IVIG) therapy were compared between the IVIG-responsive (n = 320) and IVIG-resistant (n = 85) groups. A high neutrophil-to-lymphocyte ratio and a high platelet-to-lymphocyte ratio before IVIG, especially when combined, were useful predictors for IVIG resistance in Kawasaki disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2016.07.035