Replenishing our mind orchards: Enhancing myelin renewal to rescue cognition in Alzheimer's disease

In this issue of Neuron, Chen et al. (2021) reveal dynamic changes in myelin in an Alzheimer's disease (AD) mouse model. Enhancing myelination genetically or pharmacologically improves cognition in this model, supporting myelin as a therapeutic target for AD.

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 109; no. 14; pp. 2204 - 2206
Main Authors McNamara, Niamh B, Miron, Veronique E
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 21.07.2021
Subjects
Alzheimer Disease - genetics
Alzheimer Disease - therapy
Alzheimer's disease
Animals
Cognition
Cognition & reasoning
Cognitive ability
Dementia
Disease Models, Animal
FDA approval
Gender differences
Memory
Mice
Mutation
Myelin Sheath
Myelination
Net losses
Neurodegeneration
Neurodegenerative diseases
Neurons
Neuropathology
Orchards
Pathology
Therapeutic targets
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Summary:In this issue of Neuron, Chen et al. (2021) reveal dynamic changes in myelin in an Alzheimer's disease (AD) mouse model. Enhancing myelination genetically or pharmacologically improves cognition in this model, supporting myelin as a therapeutic target for AD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2021.06.024