Long-term use of bisphosphonates in the treatment of HIV-related bone pain in perinatally infected pediatric patients

Decreased bone mineral density (BMD) is being increasingly reported as part of the metabolic syndrome related to HIV infection and to the use of antiretrovirals (ARVs) in pediatric age [1-3]. The amount of bone gained during childhood and adolescence is the main contributor to peak bone mass, which,...

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Bibliographic Details
Published inAIDS (London) Vol. 22; no. 14; pp. 1888 - 1890
Main Authors FORTUNY, Claudia, NOGUERA, Antoni, ALSINA, Laia, VILLARONGA, Miquel, VIDAL-SICART, Sergi, SANCHEZ, Emilia
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 12.09.2008
Subjects
Adolescent
Back Pain - drug therapy
Back Pain - virology
Biological and medical sciences
Bone Density Conservation Agents - therapeutic use
Bones, joints and connective tissue. Antiinflammatory agents
Child
Cohort Studies
Diphosphonates - therapeutic use
Female
HIV Infections - drug therapy
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Pharmacology. Drug treatments
Time
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Human
Immunopathology
Antiosteoporotic
Retroviridae
AIDS
Maternal diseases
Immune deficiency
Lentivirus
Bisphosphonates
Long term
Infection
Virus
Pain
Treatment
Antiosteoclastic agent
Viral disease
Vertical transmission
Bone
Human immunodeficiency virus
Child
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Summary:Decreased bone mineral density (BMD) is being increasingly reported as part of the metabolic syndrome related to HIV infection and to the use of antiretrovirals (ARVs) in pediatric age [1-3]. The amount of bone gained during childhood and adolescence is the main contributor to peak bone mass, which, in turn, is a major determinant of osteoporosis and fracture risk during adulthood. In children, osteoporosis may cause micro-fractures that lead to bone pain and disability. No specific treatment for osteoporosis is available in pediatric age. Currently, recommendations for the prevention of osteoporosis in HIV-infected children [4] suggest an adequate intake of calcium and vitamin D, appropriate weight-bearing exercise and, in HIV-infected adolescents, avoidance of alcohol and smoking.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0b013e32830c483c