Acute lung injury mechanism and therapy induced by paraquat poisoning

Paraquat (PQ, methyl viologen) was widely used in agricultural production throughout the world in 1962 for its efficient herbicidal activity. PQ was also highly toxic drug. About 5 mL medicine including 20% paraquat was life-threatening that can cause poisoning. In 1966, some people died because of...

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Bibliographic Details
Published inJournal of acute disease Vol. 6; no. 6; pp. 260 - 263
Main Authors Liu, Xian-Li, Liu, Xiao-Ran, Lu, Chuan-Zhu
Format Journal Article
LanguageEnglish
Published Medknow Publications and Media Pvt. Ltd 01.11.2017
Hainan Medical University, 3 Xueyuan Rd, Longhua District, Haikou City, Hainan Province, China 570000%Emergency Department, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China 570100
Wolters Kluwer Medknow Publications
Subjects
Acute lung injury
Adult respiratory distress syndrome
Analysis
Care and treatment
Evidence-based medicine
Health aspects
Herbicides
Inflammation
Lung diseases
Paraquat
Poisoning
Pulmonary fibrosis
Respiratory distress syndrome
Acute lung injury
Paraquat
Poisoning
Pulmonary fibrosis
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Summary:Paraquat (PQ, methyl viologen) was widely used in agricultural production throughout the world in 1962 for its efficient herbicidal activity. PQ was also highly toxic drug. About 5 mL medicine including 20% paraquat was life-threatening that can cause poisoning. In 1966, some people died because of PQ poisoning. Most patients had acute respiratory distress syndrome after 2 wk, and 70% of them died due to the lack of effective detoxification drugs. Thus, it was particularly important to understand the pathogenesis of PQ poisoning and give some effective treatments. This article will review the toxicological mechanism and treatment on PQ poisoning of acute lung injury.
ISSN:2221-6189
2221-6189
DOI:10.4103/2221-6189.221289