Circulating miR-23b as a Novel Biomarker for Early Risk Stratification After ST-Elevation Myocardial Infarction

• Published in: Medical science monitor Vol. 24; pp. 1517 - 1523
• Main Authors: Zhang, Jungang, Li, Yaxing, Zhao, Qingzhen
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 14.03.2018
• Subjects: Biomarkers - blood; Blood Glucose - metabolism; Blood Pressure; Case-Control Studies; Female; Gene Expression Regulation; Humans; Lab/In Vitro Research; Lipids - blood; Male; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; Percutaneous Coronary Intervention; Risk Assessment; ROC Curve; Smoking - adverse effects; ST Elevation Myocardial Infarction - blood; ST Elevation Myocardial Infarction - genetics; ST Elevation Myocardial Infarction - physiopathology
• ISSN: 1643-3750; 1234-1010; 1643-3750
• DOI: 10.12659/MSM.908060

BACKGROUND miR-23b overexpression can promote cardiomyocyte apoptosis and reduce cell growth under hypoxic conditions, suggesting that miR-23b acts as a biomarker for ST-elevation myocardial infarction (STEMI). The aim of this study was to investigate the effect of miR-23b on STEMI patients. MATERIAL AND METHODS We enrolled 80 eligible patients with STEMI and 60 control subjects. Blood samples were obtained at 6 h, 12 h, 24 h, 48 h, 3 days, and 7 days after the onset of symptoms. Another blood sample was collected before and after percutaneous coronary intervention (PCI). The samples were used for real-time quantitative PCR analysis. A Siemens Immulite2000 detector (Germany) was used for cTnI detection, and the serum CK-MB content was detected by electrochemical luminescence method. RESULTS The expression level of miR-23b was increased in patients with STEMI (P<0.05). No significance difference was observed among risk factors, although the clinical data was comparable (P>0.05). The level of miR-23b in STEMI patients after PCI was lower (P<0.05). The ROC curve of plasma miR-23b showed a separation, with an AUC of 0.809 (95%CI, 0.737-0.936, P<0.05), compared to CK-MB with an AUC of 0.753 (95%CI, 0.707-0.896) and cTnI with an AUC of 0.783 (95%CI, 0.723-0.917). CONCLUSIONS The present study reveals that miR-23b is a useful biomarker of STEMI, providing a novel insight for the diagnosis for STEMI.