Long non-coding RNA expression profiles reveals AK098783 is a biomarker to predict poor prognosis in patients with colorectal cancer

• Published in: Japanese journal of clinical oncology Vol. 48; no. 5; pp. 480 - 484
• Main Authors: Wang, Xiaoli, Liu, Fen, Liu, Xiaoyuan, Wang, Fang, Liao, Xiaoyu, Chen, Yuanbin, Mao, Yong, Hua, Dong, Ge, Xiaosong
• Format: Journal Article
• Language: English
• Published: England 01.05.2018
• Subjects: Biomarkers, Tumor - genetics; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - pathology; Female; Gene Expression Regulation, Neoplastic - genetics; Humans; Male; Prognosis; RNA, Long Noncoding - metabolism
• ISSN: 1465-3621; 1465-3621
• DOI: 10.1093/jjco/hyy037

Long non-coding RNAs (lncRNAs) have essential regulatory function, yet their roles in colorectal cancer (CRC) are not well understood. Microarray was applied to detect lncRNAs expression profiles in tumor tissues, liver metastasis and paired adjacent normal tissues of CRC. And using RT-PCR to verify chip results. A total of 10 680 lncRNAs demonstrated differential expressions (fold change ≥2) between tumor tissues and adjacent normal tissues; furthermore there were 2970 lncRNAs, which showed different expression level between CRC tissues with liver metastasis and adjacent normal tissues. Especially, lncRNA-AK098783 expression level was frequently higher in cancerous tissues than corresponding noncancerous tissue. Higher AK098783 expression was significantly correlated with shortened overall survival (P < 0.001) and distant metastasis (P < 0.001). Our results suggest that AK098783 is involved in distant metastasis and dramatically associated with poor prognosis in patients with CRC.