Rational design of a lipid-droplet-polarity based fluorescent probe for potential cancer diagnosis

A robust fluorescent probe CTPA has been rationally designed for cancer diagnosis by monitoring lipid drop (LD) polarity and number variation. With the outstanding properties of CTPA, we have shown that the diagnosis of cancer can be achieved not only at the cellular levels but also in organs and li...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 54; no. 85; pp. 12093 - 12096
Main Authors Yin, Junling, Peng, Min, Ma, Yanyan, Guo, Rui, Lin, Weiying
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 23.10.2018
Royal Society of Chemistry
Subjects
Cancer
Chemistry
Chemistry, Multidisciplinary
Diagnosis
Fluorescent indicators
Lipids
Medical diagnosis
Organs
Physical Sciences
Polarity
Science & Technology
FAT
SOLVENT POLARITY
DYES
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Summary:A robust fluorescent probe CTPA has been rationally designed for cancer diagnosis by monitoring lipid drop (LD) polarity and number variation. With the outstanding properties of CTPA, we have shown that the diagnosis of cancer can be achieved not only at the cellular levels but also in organs and living mice for the first time.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07398h