Characterising 18F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging

Background 18 F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of 18 F-fluciclovine in breast cancer and assessed differences in t...

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Published inBritish journal of cancer Vol. 126; no. 4; pp. 598 - 605
Main Authors Scott, N. P., Teoh, E. J., Flight, H., Jones, B. E., Niederer, J., Mustata, L., MacLean, G. M., Roy, P. G., Remoundos, D. D., Snell, C., Liu, C., Gleeson, F. V., Harris, A. L., Lord, S. R., McGowan, D. R.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 09.03.2022
Nature Publishing Group
Subjects
692/308/575
692/4028/67/1347
692/4028/67/2321
Amino acids
Biomedical and Life Sciences
Biomedicine
Breast cancer
Cancer Research
Computed tomography
Drug Resistance
Epidemiology
Molecular Medicine
Oncology
Positron emission tomography
Prostate cancer
Tomography
Tumors
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Summary:Background 18 F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of 18 F-fluciclovine in breast cancer and assessed differences in tracer kinetics and static parameters for different breast cancer receptor subtypes and tumour grades. Methods Thirty-nine patients with pathologically proven breast cancer underwent 20-min dynamic PET/computed tomography imaging following the administration of 18 F-fluciclovine. Uptake into primary breast tumours was evaluated using one- and two-tissue reversible compartmental kinetic models and static parameters. Results A reversible one-tissue compartment model was shown to best describe tracer uptake in breast cancer. No significant differences were seen in kinetic or static parameters for different tumour receptor subtypes or grades. Kinetic and static parameters showed a good correlation. Conclusions 18 F-fluciclovine has potential in the imaging of primary breast cancer, but kinetic analysis may not have additional value over static measures of tracer uptake. Clinical Trial Registration NCT03036943.
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-021-01623-3