Dietary intake of magnesium-l-threonate alleviates memory deficits induced by developmental lead exposure in rats

Elevation of brain magnesium enhances cognitive capacity. Chronic lead (Pb) exposure has been implicated in the impairment of cognition. Whether elevation of brain magnesium rescues the impairment of memory by chronic Pb exposure is still unclear. Here we investigated the effect and possible mechani...

Full description

Saved in:
Bibliographic Details
Published inRSC advances Vol. 7; no. 14; pp. 8241 - 8249
Main Authors Lou, Zhi-Yi, Chen, Weiheng, Xue, Wei-zhen, Ding, Jin-Jun, Yang, Qian-Qian, Wang, Hui-Li
Format Journal Article
LanguageEnglish
Published 01.01.2017
Subjects
Brain
Elevation
Exposure
Impairment
Intakes
Lead (metal)
Rats
Spatial analysis
Online AccessGet full text

Cover

More Information
Summary:Elevation of brain magnesium enhances cognitive capacity. Chronic lead (Pb) exposure has been implicated in the impairment of cognition. Whether elevation of brain magnesium rescues the impairment of memory by chronic Pb exposure is still unclear. Here we investigated the effect and possible mechanisms of chronic dietary intake of magnesium- l -threonate (MgT) on impaired spatial memory by chronic developmental Pb exposure in rats. We found that MgT rescued impaired spatial memory ability in Pb-exposed rats. This positive effect is relative to increasing dendritic spine density and the expression of NR2A and GluR1. Elevation of brain magnesium enhances cognitive capacity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra26959a