Chromatographic separation and assay of morphine in tablets

A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recover...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 67; no. 8; p. 1099
Main Authors Holcomb, I J, Luers, R B, Fusari, S A
Format Journal Article
LanguageEnglish
Published United States 01.08.1978
Subjects
Chromatography, Thin Layer
Methods
Morphine - analysis
Spectrophotometry, Ultraviolet
Tablets - analysis
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Summary:A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination or morphine in tablets than is the USP XVIII procedure.
ISSN:0022-3549
DOI:10.1002/jps.2600670819