Chromatographic separation and assay of morphine in tablets
A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recover...
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Published in | Journal of pharmaceutical sciences Vol. 67; no. 8; p. 1099 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.08.1978
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Subjects | |
Online Access | Get more information |
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Summary: | A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination or morphine in tablets than is the USP XVIII procedure. |
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ISSN: | 0022-3549 |
DOI: | 10.1002/jps.2600670819 |