A Supramolecular Hydrogel Inspired by Elastin
Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures,...
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| Published in | Chinese journal of chemistry Vol. 29; no. 10; pp. 2182 - 2186 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
WILEY-VCH Verlag
01.10.2011
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc |
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| Abstract | Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope （TEM）, and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc. |
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| AbstractList | Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope （TEM）, and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc. Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel bearing the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope (TEM), and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc. Self‐assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel bearing the elastin repeating peptide of VPGAG. The visco‐elasticity property, morphology of the nanostructures, and aromatic stacking in the self‐assembled nanostructure were characterized by a rheometry, transmission electron microscope (TEM), and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled‐drug release, etc. A thixotropic supramolecular hydrogel inspired by elastin was reported in this study. Self‐assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel bearing the elastin repeating peptide of VPGAG. The visco‐elasticity property, morphology of the nanostructures, and aromatic stacking in the self‐assembled nanostructure were characterized by a rheometry, transmission electron microscope (TEM), and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled‐drug release, etc . |
| Author | Wang, Shufang Hu, Yuehan Yang, Zhimou Wu, Wenjie Yang, Cuihong Tan, Ming Kong, Deling Ding, Lei |
| AuthorAffiliation | Tianjin University of Science ＆ Technology, Tianjin 300457, China Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China |
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| Keywords | DRUG self-assembly CELLS supramolecular peptide ENZYME NANOFIBERS hydrogel PH RELEASE SCAFFOLDS |
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| Notes | 31-1547/O6 Ding, Lei Wang, Shufang Wu, Wenjie Hu, Yuehan Yang, Cuihong Tan, Ming Kong, Dehing Yang, Zhimou（ 1. Tianjin University of Science ＆ Technology, Tianjin 300457, China;2. Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China） Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel beating the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope （TEM）, and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc. self-assembly, hydrogel, supramolecular, peptide the National Natural Science Foundation of China - No. 31070856 the Tianjin Technology Support Project - No. 07ZCKFSH03600 ArticleID:CJOC201180378 istex:18D1A54D3FA8346BF49B54143A10238A12792432 ark:/67375/WNG-5MGB31QZ-Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
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| Snippet | Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study... Self‐assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study... |
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| SubjectTerms | Chemistry Chemistry, Multidisciplinary hydrogel Hydrogels peptide Physical Sciences Science & Technology self-assembly supramolecular 弹力 弹性蛋白 水凝胶 生物功能材料 纳米结构 荧光显微镜 超分子 透射电子显微镜 |
| Title | A Supramolecular Hydrogel Inspired by Elastin |
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